Indian Spine Journal

SYMPOSIUM: ADOLESCENT IDIOPATHIC SCOLIOSIS
Year
: 2020  |  Volume : 3  |  Issue : 2  |  Page : 131--142

Etiology and natural history of adolescent idiopathic scoliosis: A review


Rajasekaran Shanmuganathan, Karuppanan Sukumaran Sri Vijay Anand, Ajoy P Shetty 
 Department of Spine Surgery, Ganga Medical Centre & Hospitals Pvt Ltd, Coimbatore, Tamil Nadu, India

Correspondence Address:
Dr. Rajasekaran Shanmuganathan
Department of Spine Surgery, Ganga Medical Centre & Hospitals Pvt Ltd, Mettupalayam Road, Coimbatore, Tamil Nadu.
India

Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity with a prevalence of 1.34%, although the percentage of population requiring treatment is substantially less. Understanding the etiopathogenesis and natural history of a disorder is most important to formulate effective treatment strategies. For the past few decades, researchers have probed the etiopathogenesis of AIS from various angles of genetic, neurological dysfunction, biomechanical, hormonal, and developmental disturbances. Various theories have been put forward based on association studies that found no correlation. However, direct cause–effect relationship has not been established for any individual factor till now. Also whether these findings are either primarily the cause for scoliosis or secondary to AIS remains unknown. From the existing literature, AIS appears to be a multifactorial disorder with a strong genetic predisposition, hormonal and environmental disturbances. Literature on the natural history of AIS is limited with only few studies that have long-term follow-ups on untreated scoliosis. On the basis of the available literature, it can be safely said that AIS has a benign course with very minimal or no functional disability in the long-term follow-up. The minimal risk of mortality is present only in curves of more than 100° with severe pulmonary dysfunction and cor pulmonale. Here we review the important theories, hypothesis, and recent trends in research on etiopathogenesis of AIS and also summarize on the natural history of the disorder.


How to cite this article:
Shanmuganathan R, Sri Vijay Anand KS, Shetty AP. Etiology and natural history of adolescent idiopathic scoliosis: A review.Indian Spine J 2020;3:131-142


How to cite this URL:
Shanmuganathan R, Sri Vijay Anand KS, Shetty AP. Etiology and natural history of adolescent idiopathic scoliosis: A review. Indian Spine J [serial online] 2020 [cited 2020 Nov 27 ];3:131-142
Available from: https://www.isjonline.com/article.asp?issn=2589-5079;year=2020;volume=3;issue=2;spage=131;epage=142;aulast=Shanmuganathan;type=0